Center for Integrated Solutions for Infectious Diseases

The rise in antimicrobial resistance poses a major threat to human health. We seek to unveil the underlying mechanisms of resistance – both pathogen as well as host factors that contribute to resistance evolution – and to devise new strategies to prevent, detect, and treat resistant infections. We are applying a range of methods including computation, genomics, chemical biology and structural biology, for example, to understanding the molecular mechanisms of antibiotic resistance in Neisseria gonorrhea and the evolution of carbapenem resistance in Enterobactericeae (Klebsiella pneumoniae), to develop novel strategies for antibiotic discovery against pathogens such as Mycobacterium tuberculosis, and to uncover the structural basis for herpesvirus resistance to antiviral polymerase inhibitors to guide new strategies for therapeutic development.