Infection triggers a cascade of changes in the metabolism of both the host and the microbe, which is integral to the pathogen-host interaction. We seek to understand how pathogens impact and are impacted by the metabolic pathways of their hosts – and vice versa – to determine outcomes of infection. For example, we are studying how alterations in host metabolic pathways play a role in clearance of viruses such as SARS-CoV-2 and intracellular bacteria, exploring the targeting of the pathogen respiratory chain, and characterizing the metabolic changes associated with severe sepsis in patients.